Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 7/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA6 | P23280 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235233 | 0.84 | NPC1 (0.57) | LMNACA1CA12CA4CA6 | |
| SCHEMBL8758151 | 0.84 | MET (0.56) | LMNACA1CA12CA4CA6 | |
| SCHEMBL28462539 | 0.83 | PARP10 (0.46) | LMNAL3MBTL1PRSS1MAPT | |
| SCHEMBL6552773 | 0.82 | LMNA (0.53) | LMNACA1CA12CA4CA6 | |
| SCHEMBL5703716 | 0.82 | LMNA (0.53) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16244411 | 0.82 | LMNA (0.53) | LMNACA1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16244405 | 0.82 | LMNA (0.53) | LMNACA1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15650450 | 0.82 | LMNA (0.53) | LMNAALDH1A1L3MBTL1MAPTMAOB | |
| Phenylethyl Carbamate SCHEMBL111316 | 0.82 | LMNA (0.79) | LMNACA1CA9HCAR2NPC1 | |
| SCHEMBL18740335 | 0.81 | LMNA (0.51) | LMNACA1CA12CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | disclosed |