Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364121 | 0.89 | ALDH1A1 (0.36) | GAAPOLBALDH1A1CA1CA2 | |
| SCHEMBL19363992 | 0.80 | HDAC3 (0.43) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9360405 | 0.73 | ALDH1A1 (0.46) | POLBSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL16009468 | 0.73 | HDAC3 (0.38) | GAAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL10104754 | 0.73 | ALDH1A1 (0.44) | GAAPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL22281200 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1CA1CA2HPGD | |
| SCHEMBL16010505 | 0.69 | ALDH1A1 (0.45) | GAAALDH1A1CA1CA2CA9 | |
| SCHEMBL15614381 | 0.68 | KMT2A (0.49) | GAASMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL2131080 | 0.68 | DUSP3 (0.39) | ALDH1A1LMNAMAPT | |
| SCHEMBL3545740 | 0.67 | KMT2A (0.40) | GAAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3430000-B1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC (US) | 2022-12-28 | — | — | EP | disclosed |
| US-11230532-B2 | Pyrimidines and variants thereof, and uses therefor | Afferent Pharmaceuticals, Inc. (US) | 2022-01-25 | — | — | US | disclosed |
| US-10822311-B2 | Pyrimidines and variants thereof, and uses therefor | Afferent Pharmaceuticals, Inc. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200239421-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2020-07-30 | — | — | US | disclosed |
| US-10662162-B2 | Pyrimidines and variants thereof, and uses therefor | Afferent Pharmaceuticals, Inc. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190055202-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2019-02-21 | — | — | US | disclosed |
| WO-2017165255-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2017-09-28 | — | — | WO | disclosed |
| WO-2017160569-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230532-B2 | Pyrimidines and variants thereof, and uses therefor | P2RX3, P2RX7, P2RX1 | GAA 1635/4885MGAM 4467/4885SI 2163/4885 |
| US-10662162-B2 | Pyrimidines and variants thereof, and uses therefor | P2RX3, P2RX7, P2RX1 | GAA 1650/4885MGAM 4462/4885SI 2245/4885 |
| US-10822311-B2 | Pyrimidines and variants thereof, and uses therefor | P2RX3, P2RX5, P2RX4 | GAA 1255/4885MGAM 4069/4885SI 2074/4885 |
| US-20190055202-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | P2RX3, P2RX7, P2RX1 | GAA 1650/4885MGAM 4462/4885SI 2245/4885 |
| US-20200239421-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | P2RX3, P2RX7, P2RX1 | GAA 1635/4885MGAM 4467/4885SI 2163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.