Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365302 | 0.98 | GSK3B (0.39) | GSK3BDYRK1ACPT1AATRCTPS1 | |
| SCHEMBL19670520 | 0.91 | CPT1A (0.37) | GSK3BDYRK1ACPT1AATRCTPS1 | |
| SCHEMBL19706241 | 0.90 | HDAC2 (0.35) | GSK3BDYRK1ACPT1AATRCTPS1 | |
| SCHEMBL19364891 | 0.90 | MCHR1 (0.42) | CPT1AATRMCHR1ALDH1A1HDAC2 | |
| SCHEMBL19365309 | 0.87 | CNR2 (0.40) | GSK3BATRLMNAALDH1A1MAPT | |
| SCHEMBL19364834 | 0.87 | ALDH1A1 (0.39) | GSK3BDYRK1AATRALDH1A1HDAC2 | |
| SCHEMBL19670409 | 0.87 | PRMT5 (0.42) | ATRLMNANPSR1GRM5 | |
| SCHEMBL19365441 | 0.86 | ATR (0.48) | ATRLMNANPSR1HDAC2HDAC3 | |
| SCHEMBL19365471 | 0.86 | ATR (0.36) | DYRK1AATRCTPS1LMNAALDH1A1 | |
| SCHEMBL19706240 | 0.86 | WNT1 (0.40) | DYRK1AATRLMNAALDH1A1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |