Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | XPO1 | O14980 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365464 | 1.00 | TRPV1 (0.39) | TRPV1TRPM8FAAHVCPUBE2M | |
| SCHEMBL19670319 | 0.92 | FAAH (0.42) | TRPV1FAAHVCPCACNA1HCACNA1C | |
| SCHEMBL19364826 | 0.92 | FAAH (0.42) | TRPV1FAAHVCPCACNA1HCACNA1C | |
| SCHEMBL19670325 | 0.86 | GSK3B (0.39) | TRPV1FAAHVCPCACNA1HCACNA1C | |
| SCHEMBL19365582 | 0.86 | GSK3B (0.39) | TRPV1FAAHVCPCACNA1HCACNA1C | |
| SCHEMBL17624487 | 0.85 | TRPV1 (0.40) | TRPV1TRPM8FAAHVCPUBE2M | |
| SCHEMBL17624593 | 0.85 | TRPV1 (0.40) | TRPV1TRPM8PHGDHMEN1HTT | |
| SCHEMBL19365553 | 0.84 | CNR2 (0.42) | TRPV1FAAHMEN1HTTKMT2A | |
| SCHEMBL19365560 | 0.84 | CNR2 (0.42) | TRPV1FAAHMEN1HTTKMT2A | |
| SCHEMBL19365401 | 0.82 | MALT1 (0.40) | FAAHCACNA1HJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |