Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365560 | 1.00 | CNR2 (0.42) | CNR2DRD4GRM5ALDH1A1MEN1 | |
| SCHEMBL19365409 | 0.90 | RAB9A (0.41) | CNR2DRD4GRM5MEN1KMT2A | |
| SCHEMBL19365410 | 0.90 | RAB9A (0.41) | CNR2DRD4GRM5MEN1KMT2A | |
| SCHEMBL19670319 | 0.89 | FAAH (0.42) | MEN1KMT2AHTTRAB9AGSK3B | |
| SCHEMBL19364826 | 0.89 | FAAH (0.42) | MEN1KMT2AHTTRAB9AGSK3B | |
| SCHEMBL19365401 | 0.89 | MALT1 (0.40) | CNR2DRD4RAB9AGSK3BDYRK1A | |
| SCHEMBL19365400 | 0.89 | MALT1 (0.40) | CNR2DRD4RAB9AGSK3BDYRK1A | |
| SCHEMBL19365398 | 0.84 | PRMT5 (0.40) | DRD4GRM5ALDH1A1MEN1KMT2A | |
| SCHEMBL19365582 | 0.84 | GSK3B (0.39) | MEN1KMT2AHTTGSK3BDYRK1A | |
| SCHEMBL19670325 | 0.84 | GSK3B (0.39) | MEN1KMT2AHTTGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |