Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670319 | 1.00 | FAAH (0.42) | FAAHVCPTRPV1CACNA1HCACNA1C | |
| SCHEMBL19365464 | 0.92 | TRPV1 (0.39) | FAAHVCPTRPV1CACNA1HCACNA1C | |
| SCHEMBL19365465 | 0.92 | TRPV1 (0.39) | FAAHVCPTRPV1CACNA1HCACNA1C | |
| SCHEMBL19365582 | 0.91 | GSK3B (0.39) | FAAHVCPTRPV1CACNA1HCACNA1C | |
| SCHEMBL19670325 | 0.91 | GSK3B (0.39) | FAAHVCPTRPV1CACNA1HCACNA1C | |
| SCHEMBL19365560 | 0.89 | CNR2 (0.42) | FAAHTRPV1MEN1HTTKMT2A | |
| SCHEMBL19365553 | 0.89 | CNR2 (0.42) | FAAHTRPV1MEN1HTTKMT2A | |
| SCHEMBL19670491 | 0.88 | FAAH (0.38) | FAAHKMT2AGSK3BDYRK1ANPY5R | |
| SCHEMBL19365401 | 0.87 | MALT1 (0.40) | FAAHCACNA1HJAK2NTRK1GSK3B | |
| SCHEMBL19365400 | 0.87 | MALT1 (0.40) | FAAHCACNA1HJAK2NTRK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |