Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365604 | 0.91 | HDAC1 (0.46) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19365778 | 0.88 | HDAC3 (0.39) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19365478 | 0.88 | HDAC3 (0.40) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19670240 | 0.88 | PRMT5 (0.37) | HDAC2PRMT5WDR77ATM | |
| SCHEMBL19669983 | 0.88 | HDAC1 (0.42) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19670372 | 0.86 | HDAC1 (0.36) | HDAC1HDAC2HDAC3PRMT5WDR77 | |
| SCHEMBL19670409 | 0.86 | PRMT5 (0.42) | PRMT5WDR77KDM4E | |
| SCHEMBL19365556 | 0.86 | UBE2M (0.38) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19670630 | 0.86 | HDAC1 (0.40) | HDAC1HDAC2HDAC3PRMT5WDR77 | |
| SCHEMBL19365728 | 0.85 | HDAC2 (0.43) | HDAC1HDAC2HDAC3POLBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |