Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706061 | 0.84 | KDM1A (0.41) | TRPV1PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19365572 | 0.83 | BLM (0.45) | MAPK1 | |
| SCHEMBL21841343 | 0.82 | KMO (0.41) | TRPV1PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19670247 | 0.82 | PTGS1 (0.39) | TRPV1PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19670560 | 0.81 | POLB (0.47) | TRPV1PIK3CDPIK3CAPIK3CGMAPT | |
| SCHEMBL19670601 | 0.81 | POLB (0.41) | TRPV1PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19365722 | 0.80 | POLB (0.41) | PIK3CDPIK3CAPIK3CGKMOKDM1A | |
| SCHEMBL19365636 | 0.80 | POLB (0.46) | KDRPIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19670421 | 0.80 | MPL (0.44) | TRPV1KDRPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365519 | 0.80 | POLB (0.46) | KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |