Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | WRN | Q14191 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | USP8 | P40818 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365636 | 0.85 | POLB (0.46) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL19365609 | 0.83 | TRPV1 (0.46) | MAPK1 | |
| SCHEMBL19706061 | 0.82 | KDM1A (0.41) | SMN1; SMN2ALDH1A1MAPK1CSNK2A2CSNK2B | |
| SCHEMBL19670421 | 0.81 | MPL (0.44) | ALDH1A1KMT2AMEN1POLBMPL | |
| SCHEMBL19365722 | 0.80 | POLB (0.41) | POLB | |
| SCHEMBL21841343 | 0.80 | KMO (0.41) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL19365630 | 0.80 | CTSK (0.38) | — | |
| SCHEMBL19365519 | 0.80 | POLB (0.46) | KMT2AMEN1POLB | |
| SCHEMBL19365521 | 0.80 | POLB (0.39) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL19670601 | 0.79 | POLB (0.41) | ALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |