Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.40 |
| ▸ | WNT1 | P04628 | 18/20 | 0.40 |
| ▸ | GSK3B | P49841 | 18/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670124 | 0.87 | WNT3A (0.40) | — | |
| SCHEMBL19670591 | 0.85 | FGFR4 (0.42) | — | |
| SCHEMBL19670569 | 0.84 | FAAH (0.36) | — | |
| SCHEMBL16776424 | 0.83 | DYRK1A (0.40) | DYRK1AWNT1GSK3B | |
| SCHEMBL19670620 | 0.83 | HTR2A (0.38) | — | |
| SCHEMBL19670435 | 0.82 | WNT3A (0.36) | — | |
| SCHEMBL19670532 | 0.82 | FAAH (0.41) | DYRK1AGSK3B | |
| SCHEMBL19670352 | 0.82 | HTR2C (0.47) | — | |
| SCHEMBL19706092 | 0.81 | CYP11B2 (0.37) | DYRK1ACLK2CLK3 | |
| SCHEMBL19365610 | 0.81 | BRAF (0.42) | DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |