Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365806 | 0.86 | RHOA (0.42) | RHOABRAFKDM1AFYNPOLB | |
| SCHEMBL19670403 | 0.86 | BRAF (0.39) | RHOABRAFMEN1KMT2AFYN | |
| SCHEMBL19365833 | 0.83 | RHOA (0.43) | RHOABRAFLMNABRD4CREBBP | |
| SCHEMBL19706136 | 0.83 | RHOA (0.43) | RHOABRAFBRD4CREBBPFYN | |
| SCHEMBL19670289 | 0.79 | BRAF (0.42) | RHOABRAFBRD4CREBBPFYN | |
| SCHEMBL19706060 | 0.79 | BRAF (0.42) | RHOABRAFKMT2ABRD4CREBBP | |
| SCHEMBL19365843 | 0.78 | RHOA (0.39) | RHOABRAFMEN1KMT2AHDAC1 | |
| SCHEMBL19365586 | 0.78 | RHOA (0.38) | RHOABRAFMEN1KMT2APOLB | |
| SCHEMBL19670285 | 0.77 | BRAF (0.42) | RHOABRAFBRD4CREBBPPOLB | |
| SCHEMBL19365264 | 0.76 | RHOA (0.38) | RHOAFYNMAP4K4POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |