Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365712 | 0.86 | RHOA (0.44) | BRAFRHOAMEN1KMT2AFYN | |
| SCHEMBL19365619 | 0.82 | KMO (0.37) | BRAFRHOAMAP4K4EPHB4KDR | |
| SCHEMBL19670289 | 0.82 | BRAF (0.42) | BRAFRHOAFYNMAP4K4EPHB4 | |
| SCHEMBL19365558 | 0.81 | KDR (0.40) | BRAFRHOAFYNHDAC1EPHB4 | |
| SCHEMBL19365833 | 0.77 | RHOA (0.43) | BRAFRHOAFYNEPHB4KDR | |
| SCHEMBL19706136 | 0.76 | RHOA (0.43) | BRAFRHOAFYNEPHB4KDR | |
| SCHEMBL19365806 | 0.75 | RHOA (0.42) | BRAFRHOAFYNLCKPIK3CD | |
| SCHEMBL19670382 | 0.72 | NPY5R (0.42) | BRAFFYNEPHB4KDRNPSR1 | |
| SCHEMBL29808183 | 0.70 | MEN1 (0.58) | MEN1KMT2AHDAC1HDAC6MAP4K4 | |
| SCHEMBL27994854 | 0.70 | MEN1 (0.58) | MEN1KMT2AHDAC1HDAC6MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |