Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365813 | 0.86 | RPS6KA3 (0.36) | TP53WNT3AABL1 | |
| SCHEMBL19364861 | 0.86 | NOTUM (0.40) | TP53WNT3AALDH1A1MAPT | |
| SCHEMBL19365719 | 0.83 | HTR2C (0.52) | TP53KDM4EMEN1MAPTKMT2A | |
| SCHEMBL19365327 | 0.81 | FAAH (0.36) | WNT3AGAAABL1 | |
| SCHEMBL19364831 | 0.81 | CYP11B2 (0.41) | WNT3AABL1 | |
| SCHEMBL19365819 | 0.80 | PIK3CA (0.42) | WNT3AKMT2A | |
| SCHEMBL19365610 | 0.79 | BRAF (0.42) | TP53GPR142WNT3AGAASMN1; SMN2 | |
| SCHEMBL19365531 | 0.79 | FGFR4 (0.49) | TP53GPR142WNT3AALDH1A1SMN1; SMN2 | |
| SCHEMBL17618697 | 0.78 | HRH3 (0.37) | GPR142WNT3AKDM4EABL1 | |
| SCHEMBL19670571 | 0.78 | NOTUM (0.39) | TP53WNT3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |