Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 6/20 | 0.35 |
| ▸ | KIT | P10721 | 5/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670622 | 0.90 | CSF1R (0.40) | RPS6KA3WNT3ABTKBUB1MAPK1 | |
| SCHEMBL19365719 | 0.87 | HTR2C (0.52) | HTR2AHTR2CTP53MAPK1 | |
| SCHEMBL19365733 | 0.86 | TP53 (0.38) | WNT3ATP53ABL1 | |
| SCHEMBL19364861 | 0.85 | NOTUM (0.40) | WNT3ATP53MAPK1 | |
| SCHEMBL16776211 | 0.85 | RPS6KA3 (0.43) | RPS6KA3WNT3ABTKBUB1CYP11B2 | |
| SCHEMBL19364831 | 0.84 | CYP11B2 (0.41) | WNT3AHTR2AHTR2CCYP11B2CSF1R | |
| SCHEMBL20632323 | 0.83 | GPR52 (0.39) | RPS6KA3HTR2AHTR2CTP53MAPK1 | |
| SCHEMBL19365327 | 0.82 | FAAH (0.36) | WNT3ACYP11B2RPS6KA2ABL1 | |
| SCHEMBL19365819 | 0.81 | PIK3CA (0.42) | WNT3A | |
| SCHEMBL19365738 | 0.81 | FGFR4 (0.37) | WNT3AHTR2AHTR2CCYP11B2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |