Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365587 | 0.90 | FGFR4 (0.39) | DYRK1AGSK3BWNT1CACNA1HCSF1R | |
| SCHEMBL19670360 | 0.86 | KARS1 (0.40) | KARS1DYRK1AGSK3BWNT1MAPT | |
| SCHEMBL19365599 | 0.86 | KARS1 (0.40) | KARS1DYRK1AGSK3B | |
| SCHEMBL19365732 | 0.86 | KARS1 (0.40) | KARS1DYRK1AGSK3B | |
| SCHEMBL17618647 | 0.80 | KARS1 (0.40) | KARS1GSK3BMAPT | |
| SCHEMBL16776160 | 0.80 | KARS1 (0.40) | KARS1DYRK1AGSK3BWNT1 | |
| SCHEMBL19670229 | 0.79 | POLB (0.42) | GSK3BMAPT | |
| SCHEMBL20632331 | 0.78 | DYRK1A (0.40) | DYRK1AGSK3B | |
| SCHEMBL20631979 | 0.77 | CYP11B2 (0.41) | DYRK1AGSK3B | |
| SCHEMBL19670226 | 0.77 | CNR2 (0.38) | KARS1DYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |