Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 10/20 | 0.35 |
| ▸ | DLK1 | P80370 | 2/20 | 0.35 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670356 | 0.91 | MAP3K12 (0.34) | CNR2DYRK1AGSK3BMAP3K12DLK1 | |
| SCHEMBL19670360 | 0.91 | KARS1 (0.40) | DYRK1AGSK3BMAP3K12DLK1DRG1 | |
| SCHEMBL19365756 | 0.90 | VCP (0.38) | CNR2DYRK1AGSK3BMAP3K12DLK1 | |
| SCHEMBL19670498 | 0.87 | KARS1 (0.41) | DYRK1AGSK3BKARS1TRPV1 | |
| SCHEMBL19670334 | 0.87 | FGFR4 (0.36) | DYRK1AGSK3BMAP3K12DLK1DRG1 | |
| SCHEMBL19670623 | 0.85 | KARS1 (0.38) | DYRK1AGSK3BMAP3K12KARS1TRPV1 | |
| SCHEMBL19361179 | 0.85 | CNR2 (0.36) | CNR2MAP3K12DLK1DRG1KARS1 | |
| SCHEMBL19670206 | 0.85 | DYRK1A (0.34) | CNR2DYRK1AGSK3BMAP3K12DLK1 | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | DYRK1AGSK3BTRPV1 | |
| SCHEMBL19670375 | 0.83 | TRPV1 (0.41) | DYRK1AGSK3BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |