Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DLK1 | P80370 | 2/20 | 0.35 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670226 | 0.91 | CNR2 (0.38) | KARS1MAP3K12DYRK1AGSK3BWNT1 | |
| SCHEMBL19670356 | 0.90 | MAP3K12 (0.34) | MAP3K12DYRK1AGSK3BWNT1DLK1 | |
| SCHEMBL19365380 | 0.89 | KARS1 (0.39) | KARS1MAP3K12DYRK1AGSK3BMAPT | |
| SCHEMBL19670206 | 0.87 | DYRK1A (0.34) | KARS1MAP3K12DYRK1AGSK3BWNT1 | |
| SCHEMBL19365800 | 0.86 | KARS1 (0.37) | KARS1DYRK1AGSK3BWNT1MAPT | |
| SCHEMBL19670334 | 0.86 | FGFR4 (0.36) | MAP3K12DYRK1AGSK3BWNT1DLK1 | |
| SCHEMBL17618647 | 0.85 | KARS1 (0.40) | KARS1MAP3K12GSK3BMAPTDLK1 | |
| SCHEMBL19364888 | 0.85 | WNT3A (0.39) | KARS1DYRK1AGSK3BMAPT | |
| SCHEMBL19365270 | 0.84 | WNT3A (0.40) | KARS1DYRK1AGSK3B | |
| SCHEMBL19365756 | 0.81 | VCP (0.38) | KARS1MAP3K12DYRK1AGSK3BDLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |