Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706079 | 0.93 | CA12 (0.40) | CA12CA1CA2CA9VCP | |
| SCHEMBL19365630 | 0.89 | CTSK (0.38) | CA12CA1CA2CA9VCP | |
| SCHEMBL19364862 | 0.83 | MAP4K4 (0.45) | CNR2TRPV4CTSKKCNH2 | |
| SCHEMBL19706248 | 0.83 | NAMPT (0.40) | KMOHDAC1ACP1 | |
| SCHEMBL19365722 | 0.82 | POLB (0.41) | CA12CA1CA2CA9VCP | |
| SCHEMBL19365784 | 0.81 | POLB (0.47) | CHRM2DCUN1D1 | |
| SCHEMBL19365306 | 0.81 | POLB (0.44) | CA12CA1CA2CA9VCP | |
| SCHEMBL19706158 | 0.80 | NAMPT (0.42) | — | |
| SCHEMBL19365391 | 0.80 | DGAT2 (0.42) | KMOKDM1APIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365753 | 0.79 | CA12 (0.41) | CA12CA1CA2CA9KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |