Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 9/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670534 | 0.86 | DGAT2 (0.41) | DGAT2TLR8ITGB3ITGA2BPIK3CD | |
| SCHEMBL19706158 | 0.82 | NAMPT (0.42) | — | |
| SCHEMBL19706248 | 0.82 | NAMPT (0.40) | ACP1KMO | |
| SCHEMBL19365630 | 0.82 | CTSK (0.38) | ITGB3ITGA2BKMO | |
| SCHEMBL19706079 | 0.81 | CA12 (0.40) | ITGB3ITGA2BACP1KMO | |
| SCHEMBL19365828 | 0.80 | CA12 (0.46) | ACP1KDM1APIK3CDPIK3CAPIK3CG | |
| SCHEMBL19364862 | 0.79 | MAP4K4 (0.45) | — | |
| SCHEMBL19706040 | 0.77 | KDM1A (0.40) | KDM1APIK3CDPIK3CAPIK3CG | |
| SCHEMBL21841343 | 0.76 | KMO (0.41) | KDM1APIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19670601 | 0.75 | POLB (0.41) | KDM1APIK3CDPIK3CAPIK3CGKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |