Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365389 | 0.93 | FYN (0.44) | MAPTTRPV1KDM1ARAF1BRAF | |
| SCHEMBL19670264 | 0.91 | MAPT (0.45) | MAPTTRPV1KDM1AMEN1KMT2A | |
| SCHEMBL19365580 | 0.91 | MAPT (0.43) | MAPTTRPV1KDM1ARAF1BRAF | |
| SCHEMBL19706075 | 0.89 | KDM1A (0.43) | MAPTKDM1AJAK2 | |
| SCHEMBL19365739 | 0.88 | CA2 (0.51) | MAPTKDM1AEPHX2 | |
| SCHEMBL19706288 | 0.87 | POLB (0.48) | TRPV1MEN1KMT2A | |
| SCHEMBL19365711 | 0.87 | KDM1A (0.42) | MAPTTRPV1KDM1ABRAFJAK2 | |
| SCHEMBL19706080 | 0.86 | CNR2 (0.51) | — | |
| SCHEMBL19365474 | 0.86 | MAPT (0.42) | MAPTTRPV1KDM1AEPHX2FYN | |
| SCHEMBL19365690 | 0.85 | FYN (0.38) | MAPTTRPV1KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |