Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365836 | 0.91 | MAPT (0.49) | MAPTRAF1KDM1AFYNMEN1 | |
| SCHEMBL19365389 | 0.87 | FYN (0.44) | MAPTRAF1KDM1AFYNBRAF | |
| SCHEMBL19365580 | 0.85 | MAPT (0.43) | MAPTRAF1KDM1AFYNBRAF | |
| SCHEMBL19706075 | 0.82 | KDM1A (0.43) | MAPTKDM1AJAK2 | |
| SCHEMBL19365739 | 0.81 | CA2 (0.51) | MAPTKDM1A | |
| SCHEMBL17618788 | 0.81 | MEN1 (0.46) | MAPTRAF1FYNMEN1KMT2A | |
| SCHEMBL19706288 | 0.81 | POLB (0.48) | MEN1KMT2APOLBTRPV1 | |
| SCHEMBL19365711 | 0.80 | KDM1A (0.42) | MAPTKDM1ABRAFJAK2TRPV1 | |
| SCHEMBL19365690 | 0.80 | FYN (0.38) | MAPTKDM1AFYNMEN1KMT2A | |
| SCHEMBL19670436 | 0.80 | RHOA (0.42) | MAPTKDM1AFYNBRAFJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |