Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 10/20 | 0.42 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365836 | 0.93 | MAPT (0.49) | FYNMAPTTRPV1KDM1ARAF1 | |
| SCHEMBL19670264 | 0.87 | MAPT (0.45) | FYNMAPTTRPV1KDM1ARAF1 | |
| SCHEMBL19365580 | 0.86 | MAPT (0.43) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19365690 | 0.85 | FYN (0.38) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19706075 | 0.84 | KDM1A (0.43) | MAPTKDM1AMAOBMAOAJAK2 | |
| SCHEMBL19706288 | 0.84 | POLB (0.48) | TRPV1 | |
| SCHEMBL19670436 | 0.84 | RHOA (0.42) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19365474 | 0.83 | MAPT (0.42) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19365739 | 0.83 | CA2 (0.51) | MAPTKDM1A | |
| SCHEMBL19365711 | 0.82 | KDM1A (0.42) | MAPTTRPV1KDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |