Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 8/20 | 0.37 |
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365389 | 0.85 | FYN (0.44) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19365836 | 0.85 | MAPT (0.49) | FYNMAPTTRPV1KDM1AMEN1 | |
| SCHEMBL17618335 | 0.84 | TRPV1 (0.39) | FYNMAPTTRPV1EPHB4CA2 | |
| SCHEMBL19670552 | 0.84 | FYN (0.38) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19706075 | 0.84 | KDM1A (0.43) | MAPTKDM1AMAOBMAOACA2 | |
| SCHEMBL16237553 | 0.83 | FYN (0.37) | FYNMAPTTRPV1EPHB4CA2 | |
| SCHEMBL19706043 | 0.83 | FYN (0.38) | FYNMAPTTRPV1EPHB4CA2 | |
| SCHEMBL19670264 | 0.80 | MAPT (0.45) | FYNMAPTTRPV1KDM1AMEN1 | |
| SCHEMBL19670436 | 0.80 | RHOA (0.42) | FYNMAPTTRPV1KDM1AMAOB | |
| SCHEMBL19365580 | 0.79 | MAPT (0.43) | FYNMAPTTRPV1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |