Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25615539 | 0.86 | ADRB2 (0.37) | RAB9AMAPTLMNAKDM4EPRMT5 | |
| Hydrochloric Acid SCHEMBL25211383 | 0.85 | ADRB2 (0.36) | RAB9AMAPTLMNAKDM4EPRMT5 | |
| Hydrochloric Acid SCHEMBL25268178 | 0.85 | ADRB2 (0.36) | RAB9AMAPTLMNAKDM4EPRMT5 | |
| SCHEMBL23087462 | 0.82 | HTR2A (0.46) | RAB9AMAPTLMNAKDM4EPRMT5 | |
| SCHEMBL12856337 | 0.81 | PDE2A (0.43) | RAB9AMAPTPRMT5WDR77PDE2A | |
| SCHEMBL31306342 | 0.81 | ALDH1A1 (0.41) | RAB9AMAPTKDM4EPRMT5WDR77 | |
| SCHEMBL14996666 | 0.81 | PDE2A (0.41) | RAB9ALMNAPRMT5WDR77PDE2A | |
| SCHEMBL27405097 | 0.80 | BRD4 (0.47) | RAB9AMAPTLMNAKDM4EPRMT5 | |
| SCHEMBL21051439 | 0.78 | NPC1 (0.42) | RAB9AMAPTKDM4EBRD4CREBBP | |
| SCHEMBL27037461 | 0.78 | PDE2A (0.43) | RAB9AMAPTLMNAKDM4EPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |