Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996666 | 0.84 | PDE2A (0.41) | PDE2APRMT5WDR77NPC1RAB9A | |
| SCHEMBL19369166 | 0.81 | RAB9A (0.43) | PDE2APRMT5WDR77TP53NOTUM | |
| SCHEMBL21051439 | 0.81 | NPC1 (0.42) | USP2TP53NPC1MAPTRAB9A | |
| SCHEMBL27037461 | 0.81 | PDE2A (0.43) | PDE2AMAPK1KCNH2NPC1MAPT | |
| SCHEMBL31306342 | 0.81 | ALDH1A1 (0.41) | PDE2APRMT5WDR77USP2TP53 | |
| SCHEMBL9911757 | 0.80 | PTGS2 (0.46) | PDE2APRMT5WDR77NR1H2NR1H3 | |
| SCHEMBL9933261 | 0.79 | HTR2A (0.54) | PDE2APRMT5WDR77USP2TP53 | |
| SCHEMBL14996624 | 0.78 | ALDH1A1 (0.41) | PDE2ANPC1RAB9ASMN1; SMN2BRD4 | |
| SCHEMBL14996605 | 0.78 | PDE2A (0.45) | PDE2APRMT5WDR77MAPTRAB9A | |
| SCHEMBL29096653 | 0.77 | BRD4 (0.38) | PDE2ABRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281810-B1 | AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SINOCHEM CORP (CN) | 2014-02-19 | — | — | EP | disclosed |
| US-8455398-B2 | Amide compounds, preparation methods and uses thereof | SINOCHEM CORPORATION (CN) | 2013-06-04 | — | — | US | disclosed |
| EP-2281810-A1 | AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Sinochem Corporation (CN) | 2011-02-09 | — | — | EP | disclosed |
| WO-2010034838-A2 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |