Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL925505 | 0.84 | HPGD (0.35) | ALDH1A1DHFRALKBH5KMT2AMEN1 | |
| SCHEMBL15195898 | 0.80 | ALDH1A1 (0.33) | ALDH1A1ALKBH5KMT2AMEN1ESR1 | |
| SCHEMBL15195881 | 0.77 | KMT2A (0.31) | ALDH1A1KMT2AMEN1ESR1ESR2 | |
| SCHEMBL10871333 | 0.74 | TRPA1 (0.43) | ALDH1A1KMT2AMEN1ESR1ESR2 | |
| SCHEMBL29427134 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1ESR1ESR2 | |
| SCHEMBL308275 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1ESR1ESR2 | |
| SCHEMBL13963069 | 0.73 | GABRA1 (0.46) | ALDH1A1KMT2AMEN1ESR1MAPT | |
| SCHEMBL925819 | 0.73 | GABRA1 (0.33) | — | |
| SCHEMBL967725 | 0.72 | CSNK2A1 (0.39) | ALDH1A1ESR1ESR2SKP2 | |
| SCHEMBL14496740 | 0.72 | ALDH1A1 (0.37) | ALDH1A1KMT2AMEN1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364235-B2 | Insecticidal compounds | Synenta Crop Protection LLC (US) | 2019-07-30 | — | — | US | disclosed |
| US-20180065956-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180065956-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2018-03-08 | — | — | US | disclosed |
| US-9834546-B2 | Insecticidal compounds | SYNGENTA LIMITED (GB) | 2017-12-05 | — | — | US | disclosed |
| US-9834546-B2 | Insecticidal compounds | SYNGENTA LIMITED (GB) | 2017-12-05 | — | — | US | disclosed |
| US-20170022187-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2017-01-26 | — | — | US | disclosed |
| US-20170022187-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2017-01-26 | — | — | US | disclosed |
| US-9493445-B2 | Insecticidal compounds | SYNGENTA LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-9493445-B2 | Insecticidal compounds | SYNGENTA LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-20130165485-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165485-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130131137-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131137-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2445906-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2012-05-02 | — | — | EP | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| EP-2331536-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010149506-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010020522-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022187-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, NIT2 | ALDH1A1 261/4885DHFR 2127/4885ALKBH5 2098/4885 |
| US-20130165485-A1 | INSECTICIDAL COMPOUNDS | CHRM1, CHRM2, CHRM5 | ALDH1A1 1621/4885DHFR 2817/4885ALKBH5 2060/4885 |
| US-20130131137-A1 | INSECTICIDAL COMPOUNDS | F5, CHRM1, CHRM2 | ALDH1A1 505/4885DHFR 1841/4885ALKBH5 1145/4885 |
| US-10364235-B2 | Insecticidal compounds | ACHE, CHRM1, NIT2 | ALDH1A1 261/4885DHFR 2127/4885ALKBH5 2098/4885 |
| US-20180065956-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, NIT2 | ALDH1A1 261/4885DHFR 2127/4885ALKBH5 2098/4885 |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | CHRM1, CHRM2, C1R | ALDH1A1 1154/4885DHFR 2386/4885ALKBH5 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.