Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 9/20 | 0.54 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | MERTK | Q12866 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20216832 | 0.89 | KDR (0.49) | PDGFRAKDRAXLMERTKFGFR2 | |
| SCHEMBL22104462 | 0.87 | PDGFRA (0.54) | PDGFRAKDRAXLMERTKFGFR2 | |
| SCHEMBL23939996 | 0.86 | PDGFRA (0.60) | PDGFRAKDRAXLMERTKFGFR2 | |
| SCHEMBL21769414 | 0.84 | FGFR2 (0.54) | PDGFRAKDRFGFR2PDGFRB | |
| SCHEMBL21769162 | 0.82 | MET (0.56) | PDGFRAKDRAXLMERTKFGFR2 | |
| SCHEMBL2363331 | 0.82 | AXL (0.60) | PDGFRAKDRAXLMERTK | |
| SCHEMBL19373107 | 0.82 | AXL (0.64) | PDGFRAKDRAXLMERTK | |
| SCHEMBL5570385 | 0.81 | KDR (0.57) | PDGFRAKDRAXLMERTK | |
| SCHEMBL22104168 | 0.81 | FGFR2 (0.58) | PDGFRAKDRAXLFGFR2PDGFRB | |
| SCHEMBL7480589 | 0.81 | FGFR2 (0.73) | PDGFRAKDRAXLFGFR2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896059-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2021-10-20 | — | — | EP | disclosed |
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-2409704-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2017-09-20 | — | — | EP | disclosed |