Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.62 |
| ▸ | DDO | Q99489 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SI | P14410 | 3/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713806 | 0.78 | DAO (0.56) | DAODDOFLT3PDGFRBKIT | |
| SCHEMBL8230643 | 0.78 | DAO (0.56) | DAODDOFLT3PDGFRBKIT | |
| SCHEMBL3423807 | 0.77 | DAO (1.00) | DAODDOFLT3PDGFRBKIT | |
| SCHEMBL30939503 | 0.77 | DAO (0.55) | DAODDOFLT3PDGFRBKIT | |
| SCHEMBL4071480 | 0.77 | DAO (0.55) | DAODDOFLT3PDGFRBKIT | |
| SCHEMBL27289272 | 0.75 | ALDH1A1 (0.41) | DAODDOCYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL27889601 | 0.75 | DAO (0.62) | DAODDOFLT3ALDH1A1IMPDH2 | |
| SCHEMBL28115418 | 0.75 | FLT3 (0.49) | DAODDOFLT3ALDH1A1HSD17B10 | |
| SCHEMBL28114699 | 0.75 | HRH4 (0.44) | DAODDOALDH1A1HPGDHSD17B10 | |
| SCHEMBL27277840 | 0.75 | DAO (0.62) | DAOFLT3CYP1A2CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161002-A1 | BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. (US) | 2017-09-21 | — | — | WO | disclosed |
| CN-100564375-C | (3Z) -3- (2, 3-dihydro-1H-inden-1-ylidene) -1, 3-dihydro-2H-indol-2-ones as kinase inhibitors | ALLERGAN INC (US) | 2009-12-02 | — | — | CN | disclosed |
| CN-1250526-C | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2006-04-12 | — | — | CN | disclosed |
| CN-1642944-A | (3Z) -3- (2, 3-dihydro-1H-inden-1-ylidene) -1, 3-dihydro-2H-indol-2-ones as kinase inhibitors | ALLERGAN INC (US) | 2005-07-20 | — | — | CN | disclosed |
| CN-1541098-A | Combination therapy for treatment of cancer | �ո��� | 2004-10-27 | — | — | CN | disclosed |
| CN-1349416-A | Contraceptive compositions contaiing indoline derivatives and progestational agents | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1311775-A | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN INC (US) | 2001-09-05 | — | — | CN | disclosed |