SCHEMBL1937529

SCHEMBL1937529

CNC(F)(c1ccccc1)C(F)(F)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 5/20 0.48
TSHR P16473 3/20 0.42
ALDH1A1 P00352 1/20 0.42
PTPN1 P18031 1/20 0.34
MAPK1 P28482 1/20 0.33
LMNA P02545 1/20 0.33
CYP2D6 P10635 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA5A P35218 1/20 0.33
CA9 Q16790 1/20 0.33
NR1H2 P55055 3/20 0.32
NR1H3 Q13133 2/20 0.32
KIF11 P52732 1/20 0.32
PDK1 Q15118 2/20 0.32
PDK2 Q15119 2/20 0.32
PDK3 Q15120 2/20 0.32
PDK4 Q16654 2/20 0.32
NR3C2 P08235 1/20 0.32
HDAC3 O15379 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1937895 0.78 KCNN4 (0.53) KCNN4TSHRALDH1A1PTPN1LMNA
SCHEMBL1414621 0.77 ALDH1A1 (0.41) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL9784343 0.75 MAPT (0.39) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL28382009 0.73 KCNN4 (0.52) KCNN4TSHRALDH1A1PTPN1MAPK1
Dimethylamine SCHEMBL4059229 0.72 KCNN4 (0.41) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL3879900 0.72 KCNN4 (0.56) KCNN4TSHRALDH1A1PTPN1MAPK1
Hydrochloric Acid SCHEMBL4028283 0.71 KCNN4 (0.50) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL9784435 0.71 ALDH1A1 (0.35) TSHRALDH1A1PTPN1LMNACA1
Dimethylamine SCHEMBL9561223 0.70 KCNN4 (0.48) KCNN4TSHRALDH1A1PTPN1MAPK1
Trifluoromethylbenzene SCHEMBL1768875 0.69 TSHR (0.78) KCNN4TSHRALDH1A1MAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331620-A1 CURABLE COMPOSITION AND MOLDED ARTICLE MADE OF SAME Daikin Industries, Ltd. (JP) 2011-06-15 EP disclosed