Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.34 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16028600 | 0.83 | TRPC5 (0.48) | ADORA3TRPC4TRPC5TRPC1PDE5A | |
| SCHEMBL19375424 | 0.81 | TRPC4 (0.41) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL18834408 | 0.76 | TRPC5 (0.44) | ADORA3ADORA2BTRPC4TRPC5TRPC1 | |
| SCHEMBL18834315 | 0.76 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL16028545 | 0.75 | TRPC5 (0.57) | TRPC4TRPC5TRPC1KCNH2 | |
| SCHEMBL18834600 | 0.73 | PDE4A (0.32) | PDE4APDE4BPDE4CPDE4DADORA3 | |
| SCHEMBL19375225 | 0.72 | TP53 (0.41) | TRPC4TRPC5TRPC1KCNH2 | |
| SCHEMBL16028630 | 0.70 | TRPC5 (0.56) | TRPC4TRPC5TRPC1KCNH2 | |
| SCHEMBL19375019 | 0.70 | TRPC4 (0.42) | TRPC4TRPC5TRPC1KCNH2 | |
| SCHEMBL18834631 | 0.68 | TRPC5 (0.53) | ADORA3TRPC4TRPC5TRPC1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |