Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.43 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.35 |
| ▸ | TSHR | P16473 | 9/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.35 |
| ▸ | USP2 | O75604 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19505247 | 0.92 | TSHR (0.35) | TRPC5TRPC4KCNH2TRPC1CYP2C9 | |
| SCHEMBL20432298 | 0.91 | TRPC5 (0.33) | TRPC5TRPC4KCNH2TRPC1P2RX3 | |
| SCHEMBL21499681 | 0.91 | P2RX3 (0.40) | TRPC5TRPC4KCNH2P2RX3 | |
| SCHEMBL21499685 | 0.89 | TRPC5 (0.43) | TRPC5TRPC4KCNH2TRPC1 | |
| SCHEMBL22619613 | 0.86 | TRPC5 (0.57) | TRPC5TRPC4KCNH2TRPC1CYP1A2 | |
| SCHEMBL19505557 | 0.86 | P2RX3 (0.34) | KCNH2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20432276 | 0.84 | TRPC5 (0.34) | TRPC5TRPC4TRPC1P2RX3 | |
| SCHEMBL18834309 | 0.82 | TRPC5 (0.44) | TRPC5TRPC4KCNH2TRPC1CYP1A2 | |
| SCHEMBL19505249 | 0.82 | TRPC5 (0.49) | TRPC5TRPC4KCNH2TRPC1ALDH1A1 | |
| SCHEMBL19505333 | 0.82 | P2RX3 (0.38) | TRPC5TRPC4KCNH2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |