Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375459 | 0.92 | TRPC5 (0.43) | TSHRKMT2AMEN1ALDH1A1TRPC4 | |
| SCHEMBL20432298 | 0.92 | TRPC5 (0.33) | TRPC4TRPC5KCNH2L3MBTL1TRPC1 | |
| SCHEMBL21499685 | 0.90 | TRPC5 (0.43) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL21499681 | 0.87 | P2RX3 (0.40) | TRPC4TRPC5KCNH2 | |
| SCHEMBL19505557 | 0.87 | P2RX3 (0.34) | TSHRALDH1A1KCNH2HTTSMN1; SMN2 | |
| SCHEMBL20432276 | 0.85 | TRPC5 (0.34) | TRPC4TRPC5TRPC1 | |
| SCHEMBL19505249 | 0.85 | TRPC5 (0.49) | TSHRKMT2AMEN1ALDH1A1TRPC4 | |
| SCHEMBL19505167 | 0.83 | HTT (0.36) | TSHRNPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL19505333 | 0.78 | P2RX3 (0.38) | TRPC4TRPC5KCNH2 | |
| SCHEMBL19505559 | 0.78 | PDE5A (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969736-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | TRPC5, TRPC7, TRPC4 | TSHR 4540/4885NPSR1 836/4885KMT2A 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.