Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.35 |
| ▸ | PDE2A | O00408 | 8/20 | 0.35 |
| ▸ | PDE6D | O43924 | 2/20 | 0.35 |
| ▸ | PDE6A | P16499 | 2/20 | 0.35 |
| ▸ | PDE6G | P18545 | 2/20 | 0.35 |
| ▸ | PDE6B | P35913 | 2/20 | 0.35 |
| ▸ | PDE6C | P51160 | 2/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1937435 | 0.90 | KDM4E (0.37) | MAPTSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL1559111 | 0.83 | NPC1 (0.37) | NPC1RAB9AMAPTCRHBPCRHR2 | |
| SCHEMBL1937723 | 0.82 | ABL1 (0.38) | NPC1RAB9AMAPTSMN1; SMN2PDE10A | |
| SCHEMBL1162736 | 0.81 | ALDH1A1 (0.33) | PDE10APDE2APDE6DPDE6APDE6G | |
| SCHEMBL1937991 | 0.78 | ABL1 (0.39) | NPC1RAB9AMAPTSMN1; SMN2PDE10A | |
| SCHEMBL1937699 | 0.75 | ABL1 (0.37) | NPC1RAB9AMAPTCRHBPCRHR2 | |
| SCHEMBL29184356 | 0.73 | MEN1 (0.34) | PDE10APDE2AAMY1A | |
| SCHEMBL30284776 | 0.73 | MEN1 (0.34) | PDE10APDE2AAMY1A | |
| SCHEMBL1937701 | 0.72 | TP53 (0.36) | NPC1RAB9AMAPTSMN1; SMN2PDE10A | |
| SCHEMBL1938695 | 0.72 | DHODH (0.41) | NPC1RAB9APDE10APDE2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2330891-A1 | FUNGICIDAL PYRIDAZINES | E. I. du Pont de Nemours and Company (US) | 2011-06-15 | — | — | EP | claimed |
| US-20110136762-A1 | FUNGICIDAL PYRIDAZINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-09 | — | — | US | claimed |
| WO-2010036553-A1 | FUNGICIDAL PYRIDAZINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-04-01 | — | — | WO | claimed |
| EP-2330891-A1 | FUNGICIDAL PYRIDAZINES | E. I. du Pont de Nemours and Company (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110136762-A1 | FUNGICIDAL PYRIDAZINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-09 | — | — | US | disclosed |
| WO-2010036553-A1 | FUNGICIDAL PYRIDAZINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136762-A1 | FUNGICIDAL PYRIDAZINES | PRDX1, PNPO, PRXL2A | NPC1 1393/4885RAB9A 1912/4885MAPT 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.