Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375553 | 0.81 | ALDH1A1 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18834562 | 0.76 | P2RX7 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18834221 | 0.72 | P2RX3 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18834196 | 0.69 | ALDH1A1 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20432551 | 0.66 | SMN1; SMN2 (0.35) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20432418 | 0.66 | ALDH1A1 (0.47) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18833638 | 0.65 | USP1 (0.38) | — | |
| SCHEMBL19374868 | 0.65 | P2RX3 (0.36) | ADORA3P2RX7BRD4P2RX3 | |
| SCHEMBL8007895 | 0.64 | PDE5A (0.39) | PDE5ABRD4 | |
| SCHEMBL19375292 | 0.61 | HCRTR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |