Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936766 | 0.90 | TYMS (0.32) | PDK2CA1CA2 | |
| SCHEMBL869547 | 0.89 | PDK2 (0.42) | PDK2CA1CA2KDM4EMAPT | |
| SCHEMBL12173998 | 0.84 | — | — | |
| SCHEMBL16692835 | 0.83 | PDK2 (0.40) | PDK2KDM4EMAPTMEN1MAPK1 | |
| SCHEMBL869871 | 0.83 | PDK2 (0.40) | PDK2CA1CA2KDM4EMAPT | |
| SCHEMBL980171 | 0.83 | PDK2 (0.39) | PDK2KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL516607 | 0.82 | PDK2 (0.37) | PDK2CA1CA2KDM4EMAPK1 | |
| SCHEMBL17049136 | 0.81 | PDK2 (0.37) | PDK2CA1CA2 | |
| SCHEMBL738679 | 0.81 | CA1 (0.37) | PDK2CA1CA2KDM4EMAPT | |
| SCHEMBL870037 | 0.81 | PDK2 (0.43) | PDK2CA1CA2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9282742-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2016-03-15 | — | — | US | disclosed |
| US-9282742-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2016-03-15 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| EP-2331535-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-07-22 | — | — | EP | disclosed |
| EP-2331535-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-07-22 | — | — | EP | disclosed |
| US-20140350061-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2014-11-27 | — | — | US | disclosed |
| US-20140350061-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2014-11-27 | — | — | US | disclosed |
| US-20140350061-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2014-11-27 | — | — | US | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110166193-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166193-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166193-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2331535-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| EP-2331536-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010025998-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010025998-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020522-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020522-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350061-A1 | INSECTICIDAL COMPOUNDS | CHRM1, ACHE, CHRM2 | PDK2 4141/4885CA1 631/4885CA2 195/4885 |
| US-20110166193-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, MSL1 | PDK2 3788/4885CA1 1048/4885CA2 685/4885 |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | CHRM1, CHRM2, C1R | PDK2 4816/4885CA1 1254/4885CA2 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.