Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19376396 | 0.98 | SIGMAR1 (0.56) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL18585349 | 0.95 | MAOA (0.56) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL29174525 | 0.93 | SIGMAR1 (0.56) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL29174515 | 0.93 | SIGMAR1 (0.56) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL19376376 | 0.93 | SIGMAR1 (0.56) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL150875 | 0.92 | SIGMAR1 (0.52) | MAOAMAOBSIGMAR1L3MBTL1HTR2A | |
| SCHEMBL149171 | 0.87 | SIGMAR1 (0.52) | MAOAMAOBSIGMAR1L3MBTL1HTR2A | |
| Fluoride Ion SCHEMBL12481878 | 0.87 | SIGMAR1 (0.52) | MAOAMAOBSIGMAR1L3MBTL1HTR2A | |
| Hydrochloric Acid SCHEMBL30393129 | 0.84 | MAOA (0.67) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL451456 | 0.84 | MAOA (0.74) | MAOAMAOBSIGMAR1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856337-B2 | Polymerization catalysts | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-01-02 | — | — | US | claimed |
| US-20170275402-A1 | POLYMERIZATION CATALYSTS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2017-09-28 | — | — | US | claimed |
| US-9856337-B2 | Polymerization catalysts | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170275402-A1 | POLYMERIZATION CATALYSTS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275402-A1 | POLYMERIZATION CATALYSTS | SIK2, SIK3, SGK2 | MAOA 3985/4885MAOB 3586/4885SIGMAR1 2654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.