Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732195 | 0.86 | THRB (0.68) | THRBHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL14415899 | 0.85 | THRB (0.77) | THRBHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL25328235 | 0.85 | THRB (0.77) | THRBHDAC1HDAC6MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4780686 | 0.85 | THRB (0.66) | THRBHDAC1HDAC6MEN1KMT2A | |
| N-Hydroxymethylnicotinamide SCHEMBL352358 | 0.84 | THRB (1.00) | THRBHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL10894696 | 0.83 | EPHX2 (0.68) | THRBMEN1KMT2ANPC1RAB9A | |
| Nicotinic Acid Hydrazide SCHEMBL258390 | 0.83 | HDAC1 (0.69) | THRBHDAC1HDAC6MEN1KMT2A | |
| Nicotinic Acid Hydrazide SCHEMBL29648965 | 0.83 | HDAC1 (0.69) | THRBHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL1687071 | 0.83 | THRB (0.73) | THRBHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL8403704 | 0.83 | THRB (0.73) | THRBHDAC1HDAC6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160287712-A1 | FATTY ACID NIACIN CONJUGATES | CATABASIS PHARMACEUTICALS INC (US) | 2016-10-06 | — | — | US | disclosed |
| US-20160287712-A1 | FATTY ACID NIACIN CONJUGATES | CATABASIS PHARMACEUTICALS INC (US) | 2016-10-06 | — | — | US | disclosed |
| US-9024022-B2 | Substrates of O6-alkylguanine-DNA alkyltransferase and mutants thereof | CIS BIO INTERNATIONAL (FR) | 2015-05-05 | — | — | US | disclosed |
| EP-2331510-B1 | SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (AGT) AND THEIR USE IN METHOD OF LABELLING | ION BEAM APPLIC SA (BE) | 2013-11-06 | — | — | EP | disclosed |
| US-20110236952-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS BIO INTERNATIONAL (FR) | 2011-09-29 | — | — | US | disclosed |
| EP-2331510-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS Bio International (FR) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010034931-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS-BIO INTERNATIONAL (FR) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110236952-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | OGG1, UNG, MPG | THRB 3061/4885HDAC1 1945/4885HDAC6 3207/4885 |
| US-20160287712-A1 | FATTY ACID NIACIN CONJUGATES | NAMPT, NAPRT, FASN | THRB 1753/4885HDAC1 1656/4885HDAC6 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.