Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 16/20 | 0.65 |
| ▸ | NOS2 | P35228 | 12/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | NOS3 | P29474 | 8/20 | 0.57 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19379236 | 1.00 | NOS1 (0.65) | NOS1NOS2KCNH2SLC6A2NOS3 | |
| SCHEMBL2675490 | 0.92 | NOS1 (0.65) | NOS1NOS2KCNH2SLC6A2NOS3 | |
| SCHEMBL2674197 | 0.86 | NOS1 (0.58) | NOS1NOS2KCNH2SLC6A2NOS3 | |
| SCHEMBL14208338 | 0.85 | HTR1A (0.52) | NOS1NOS2KCNH2SLC6A2NOS3 | |
| SCHEMBL2674521 | 0.81 | NOS1 (0.61) | NOS1NOS2KCNH2SLC6A2NOS3 | |
| SCHEMBL2777995 | 0.78 | NOS1 (0.62) | NOS1NOS2KCNH2NOS3HTR1B | |
| SCHEMBL12391669 | 0.78 | NOS1 (0.54) | NOS1NOS2KCNH2NOS3HTR1B | |
| Hydrochloric Acid SCHEMBL2675849 | 0.77 | NOS1 (0.62) | NOS1NOS2KCNH2NOS3HTR1B | |
| SCHEMBL2676021 | 0.76 | NOS1 (0.63) | NOS1NOS2KCNH2NOS3HTR1B | |
| SCHEMBL2675450 | 0.75 | NOS1 (0.48) | NOS1NOS2KCNH2NOS3HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331910-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | UNIV NORTHWESTERN (US) | 2020-10-22 | — | — | US | disclosed |
| US-10759791-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2020-09-01 | — | — | US | disclosed |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331910-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | NOS1 1/4885NOS2 2/4885KCNH2 4547/4885 |
| US-20170275278-A1 | Mammalian and Bacterial Nitric Oxide Synthase Inhibitors | NOS1, NOS2, NOS3 | NOS1 1/4885NOS2 2/4885KCNH2 4547/4885 |
| US-10759791-B2 | Mammalian and bacterial nitric oxide synthase inhibitors | NOS1, NOS2, NOS3 | NOS1 1/4885NOS2 2/4885KCNH2 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.