Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688670 | 0.77 | AHR (0.45) | DAOKDM4EBRD4AHRCA12 | |
| SCHEMBL715895 | 0.76 | DAO (0.65) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL31426215 | 0.76 | DAO (0.65) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL14159651 | 0.74 | DAO (0.44) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL7163743 | 0.74 | KDM4E (0.52) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL434663 | 0.73 | KDM4E (0.50) | DAOKDM4EBRPF1TP53CA12 | |
| SCHEMBL15241831 | 0.72 | DAO (0.40) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL18317487 | 0.71 | SMN1; SMN2 (0.60) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL15241820 | 0.71 | SMN1; SMN2 (0.43) | DAOKDM4EKLK7BRD4BRPF1 | |
| SCHEMBL28723434 | 0.71 | ALDH1A1 (0.53) | DAOKDM4EKLK7TP53NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170273970-A1 | Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders | Grünenthal GmbH (DE) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273970-A1 | Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders | TSPO, TPMT, HLA-DRB1 | DAO 728/4885KDM4E 4306/4885KLK7 3695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.