SCHEMBL715895

SCHEMBL715895

Cc1cc2ccccc2n(C)c1=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.65
BRPF1 P55201 4/20 0.61
BRD4 O60885 3/20 0.52
CA12 O43570 1/20 0.52
CA9 Q16790 1/20 0.52
KAT2B Q92831 1/20 0.52
BRD9 Q9H8M2 1/20 0.52
AHR P35869 3/20 0.51
MCL1 Q07820 1/20 0.50
KMT2A Q03164 4/20 0.48
DDB1 Q16531 1/20 0.48
CRBN Q96SW2 1/20 0.48
KDM4E B2RXH2 5/20 0.47
NQO2 P16083 1/20 0.47
KLK7 P49862 1/20 0.47
BRD1 O95696 2/20 0.46
GAA P10253 1/20 0.45
PKM P14618 1/20 0.45
CASP1 P29466 1/20 0.45
GALK1 P51570 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31426215 1.00 DAO (0.65) DAOBRPF1BRD4CA12CA9
SCHEMBL29079027 0.79 DAO (0.64) DAOBRPF1BRD4CA12CA9
SCHEMBL30574135 0.79 DAO (0.64) DAOBRPF1BRD4CA12CA9
SCHEMBL30349848 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL21955107 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL8538250 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL1421868 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL31039545 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL29891722 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9
SCHEMBL28165616 0.78 DAO (0.62) DAOBRPF1BRD4CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230295180-A1 PROTEIN DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-21 US disclosed
EP-4227304-A2 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2023-08-16 EP disclosed
US-20230234950-A1 CRBN LIGANDS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-27 US disclosed
WO-2023006893-A1 COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING CONFO THERAPEUTICS N.V. (BE) 2023-02-02 WO disclosed
CN-111196817-B Tricyclic compounds as BRPF1 inhibitors 四川大学华西医院 2021-06-11 CN disclosed
EP-3736271-A1 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2020-11-11 EP disclosed
US-20200347045-A1 CRBN LIGANDS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2020-11-05 US disclosed
CN-111196817-A Tricyclic compounds as BRPF1 inhibitors 四川大学华西医院 2020-05-26 CN disclosed
US-20200115343-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2020-04-16 US disclosed
US-10577329-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors FORMA THERAPEUTICS, INC. (US) 2020-03-03 US disclosed
EP-3194375-A1 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS Forma Therapeutics, Inc. (US) 2017-07-26 EP disclosed
US-9624175-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors FORMA THERAPEUTICS, INC. (US) 2017-04-18 US disclosed
US-20160311774-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2016-10-27 US disclosed
WO-2016044782-A1 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. (US) 2016-03-24 WO disclosed
US-20150218175-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2015-08-06 US disclosed
WO-2014116845-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-31 WO disclosed
US-8653102-B2 Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators GRUENENTHAL GMBH (DE) 2014-02-18 US disclosed
US-20120053206-A1 Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators GRUNENTHAL GMBH (DE) 2012-03-01 US disclosed
EP-1485378-B1 PIPERAZINYL-, PIPERIDINYL- AND MORPHOLINYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE JANSSEN PHARMACEUTICA NV (BE) 2008-06-18 EP disclosed
EP-1485365-B1 SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE JANSSEN PHARMACEUTICA NV (BE) 2008-05-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230234950-A1 CRBN LIGANDS AND USES THEREOF CRBN, CRKL, ERBB3 DAO 3735/4885BRPF1 1576/4885BRD4 1883/4885
US-20200347045-A1 CRBN LIGANDS AND USES THEREOF CRBN, CRKL, ERBB3 DAO 3735/4885BRPF1 1576/4885BRD4 1883/4885
US-20230295180-A1 PROTEIN DEGRADERS AND USES THEREOF MDM2, CUL1, PSMG3 DAO 837/4885BRPF1 2350/4885BRD4 941/4885
US-20160311774-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH1, IDH3A, IDH3B DAO 975/4885BRPF1 1481/4885BRD4 135/4885
US-20120053206-A1 Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators KCNQ1, KCNQ2, KCNQ3 DAO 3432/4885BRPF1 2272/4885BRD4 191/4885
US-10577329-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors IDH1, IDH3A, IDH3B DAO 975/4885BRPF1 1481/4885BRD4 135/4885
US-20150218175-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS SMN1; SMN2, SF3B5, SF3B1 DAO 2429/4885BRPF1 3791/4885BRD4 1785/4885
US-20200115343-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH1, IDH3A, IDH3B DAO 975/4885BRPF1 1481/4885BRD4 135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.