Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463688 | 0.82 | L3MBTL1 (0.37) | KDM4EGAAALDH1A1LMNAMAPK1 | |
| SCHEMBL2197479 | 0.76 | GAA (0.46) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL514305 | 0.71 | RAB9A (0.50) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL2092221 | 0.71 | KMT2A (0.42) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL2092778 | 0.71 | GRIK1 (0.37) | MEN1KMT2ATDP1 | |
| SCHEMBL1939409 | 0.71 | GAA (0.45) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL227130 | 0.71 | CYP1A2 (0.44) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL225740 | 0.71 | NPC1 (0.50) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL1335991 | 0.71 | MAPT (0.56) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL2677107 | 0.71 | MAPT (0.71) | MAPTKDM4EGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073425-B | Compound serving as TBK1 inhibitor, pharmaceutical composition containing compound and application of compound | 中国科学院上海药物研究所 | 2023-11-14 | — | — | CN | claimed |
| CN-115073425-A | Compound serving as TBK1 inhibitor, pharmaceutical composition containing compound and application of compound | 中国科学院上海药物研究所 | 2022-09-20 | — | — | CN | claimed |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | TRUSTEES OF BOSTON UNIVERSITY (US) | 2018-10-02 | — | — | US | claimed |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-10 | — | — | US | claimed |
| WO-2014116962-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2014-07-31 | — | — | WO | claimed |
| EP-2676956-A1 | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof | Purdue Pharma L.P. (US) | 2013-12-25 | — | — | EP | claimed |
| EP-2331522-B1 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA LP (US) | 2013-09-18 | — | — | EP | claimed |
| US-20130150377-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | SHIONOGI & CO., LTD. (JP) | 2013-06-13 | — | — | US | claimed |
| US-8324249-B2 | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2012-12-04 | — | — | US | claimed |
| JP-2011529884-A | — | — | 2011-12-15 | — | — | JP | claimed |
| EP-2331522-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | Purdue Pharma LP (US) | 2011-06-15 | — | — | EP | claimed |
| US-20110136833-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | SHINOGI & CO., LTD. (JP) | 2011-06-09 | — | — | US | claimed |
| WO-2010014257-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. (US) | 2010-02-04 | — | — | WO | claimed |
| CN-115073425-B | Compound serving as TBK1 inhibitor, pharmaceutical composition containing compound and application of compound | 中国科学院上海药物研究所 | 2023-11-14 | — | — | CN | disclosed |
| CN-115073425-A | Compound serving as TBK1 inhibitor, pharmaceutical composition containing compound and application of compound | 中国科学院上海药物研究所 | 2022-09-20 | — | — | CN | disclosed |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | TRUSTEES OF BOSTON UNIVERSITY (US) | 2018-10-02 | — | — | US | disclosed |
| EP-2331522-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | Purdue Pharma LP (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110136833-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | SHINOGI & CO., LTD. (JP) | 2011-06-09 | — | — | US | disclosed |
| WO-2010014257-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. (US) | 2010-02-04 | — | — | WO | disclosed |
| CN-1705670-A | 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds | OTSUKA PHARMA CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150377-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | TRPV1, CACNA1A, CACNA1E | MAPT 1173/4885KDM4E 1591/4885GAA 2938/4885 |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | HDAC8, HDAC1, HDAC7 | MAPT 1009/4885KDM4E 292/4885GAA 186/4885 |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | HDAC8, HDAC1, HDAC11 | MAPT 1172/4885KDM4E 259/4885GAA 208/4885 |
| US-20110136833-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | TRPV1, CACNA1A, CACNA1E | MAPT 1173/4885KDM4E 1591/4885GAA 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.