Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3567348 | 0.82 | LMNA (0.46) | GAANPC1HTTLMNATP53 | |
| SCHEMBL11463688 | 0.82 | L3MBTL1 (0.37) | GAANPC1HTTLMNATP53 | |
| SCHEMBL9463502 | 0.76 | RAB9A (0.41) | GAANPC1HTTLMNATP53 | |
| SCHEMBL10467336 | 0.74 | MAPT (0.42) | GAANPC1KMT2AMAPTMEN1 | |
| SCHEMBL3562173 | 0.73 | CA2 (0.39) | GAANPC1HTTLMNAMAPT | |
| SCHEMBL3562013 | 0.73 | CXCR1 (0.42) | GAANPC1KMT2AMAPTMEN1 | |
| SCHEMBL514305 | 0.71 | RAB9A (0.50) | GAANPC1HTTKMT2AMAPT | |
| SCHEMBL1938533 | 0.71 | MAPT (0.46) | GAANPC1HTTLMNATP53 | |
| SCHEMBL2092221 | 0.71 | KMT2A (0.42) | GAANPC1HTTLMNAKMT2A | |
| SCHEMBL28288384 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | TRUSTEES OF BOSTON UNIVERSITY (US) | 2018-10-02 | — | — | US | claimed |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-10 | — | — | US | claimed |
| WO-2014116962-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2014-07-31 | — | — | WO | claimed |
| EP-2676956-A1 | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof | Purdue Pharma L.P. (US) | 2013-12-25 | — | — | EP | claimed |
| EP-2331522-B1 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA LP (US) | 2013-09-18 | — | — | EP | claimed |
| US-20130150377-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | SHIONOGI & CO., LTD. (JP) | 2013-06-13 | — | — | US | claimed |
| US-8324249-B2 | Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2012-12-04 | — | — | US | claimed |
| JP-2011529884-A | — | — | 2011-12-15 | — | — | JP | claimed |
| EP-2331522-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | Purdue Pharma LP (US) | 2011-06-15 | — | — | EP | claimed |
| US-20110136833-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | SHINOGI & CO., LTD. (JP) | 2011-06-09 | — | — | US | claimed |
| US-20100256139-A1 | Anti-Viral Compounds | ABBOTT LABORATORIES (US) | 2010-10-07 | — | — | US | claimed |
| EP-1979349-B1 | ANTI-VIRAL COMPOUNDS | ABBOTT LAB (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2010014257-A2 | TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. (US) | 2010-02-04 | — | — | WO | claimed |
| EP-1979349-A2 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2008-10-15 | — | — | EP | claimed |
| US-20070232645-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. | 2007-10-04 | — | — | US | claimed |
| WO-2007076035-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-07-05 | — | — | WO | claimed |
| EP-0879223-A1 | AROMATIC POLYCYCLIC RETINOID-TYPE DERIVATIVES, METHOD FOR PREPARING SAME, AND USE THEREOF FOR MAKING PHARMACEUTICAL AND COSMETIC COMPOSITIONS | Centre Europeen de Bioprospective -CEB (FR) | 1998-11-25 | — | — | EP | claimed |
| WO-1997026237-A1 | AROMATIC POLYCYCLIC RETINOID-TYPE DERIVATIVES, METHOD FOR PREPARING SAME, AND USE THEREOF FOR MAKING PHARMACEUTICAL AND COSMETIC COMPOSITIONS | CENTRE EUROPEEN DE BIOPROSPECTIVE - CEB (FR) | 1997-07-24 | — | — | WO | claimed |
| US-4698349-A | Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | claimed |
| EP-0157346-A2 | Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-09 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150377-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | TRPV1, CACNA1A, CACNA1E | GAA 2938/4885NPC1 917/4885HTT 1259/4885 |
| US-20070232645-A1 | ANTI-VIRAL COMPOUNDS | HAVCR2, MAVS, EIF2AK2 | GAA 504/4885NPC1 37/4885HTT 472/4885 |
| US-20100256139-A1 | Anti-Viral Compounds | HAVCR2, MAVS, EIF2AK2 | GAA 504/4885NPC1 37/4885HTT 472/4885 |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | HDAC8, HDAC1, HDAC7 | GAA 186/4885NPC1 963/4885HTT 331/4885 |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | HDAC8, HDAC1, HDAC11 | GAA 208/4885NPC1 1204/4885HTT 292/4885 |
| US-20110136833-A1 | Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof | TRPV1, CACNA1A, CACNA1E | GAA 2938/4885NPC1 917/4885HTT 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.