Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323966 | 0.77 | PARP1 (0.56) | PARP1RNASEH1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL15271657 | 0.70 | TSHR (0.54) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL26688876 | 0.70 | ALDH1A1 (0.46) | PARP1ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL9126680 | 0.69 | PARP1 (0.56) | PARP1RNASEH1ALDH1A1CYP3A4TSHR | |
| SCHEMBL2018005 | 0.68 | LMNA (0.62) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| Butylbenzyl SCHEMBL27296811 | 0.68 | ALDH1A1 (0.79) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL2021418 | 0.67 | LMNA (0.60) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| Hexane SCHEMBL28355428 | 0.67 | LMNA (0.60) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL7323950 | 0.67 | PARP1 (0.56) | PARP1RNASEH1ALDH1A1LMNADAO | |
| SCHEMBL20656207 | 0.67 | MMP2 (0.47) | MMP1MMP2MMP12ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3433247-A1 | 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS | Bristol-Myers Squibb Company (US) | 2019-01-30 | — | — | EP | disclosed |
| WO-2017165640-A1 | 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-28 | — | — | WO | disclosed |