Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | DAO | P14920 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323950 | 0.84 | PARP1 (0.56) | PARP1ALDH1A1HPGDMAPTRNASEH1 | |
| SCHEMBL7378035 | 0.79 | MAPT (0.47) | ALDH1A1HPGDMAPTRNASEH1SMN1; SMN2 | |
| SCHEMBL28236562 | 0.77 | ALDH1A1 (0.50) | PARP1ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL5380589 | 0.77 | GSK3B (0.56) | PARP1LMNADAOMEN1KMT2A | |
| SCHEMBL19386255 | 0.77 | PARP1 (0.47) | PARP1ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL7321697 | 0.75 | PARP1 (0.54) | PARP1RNASEH1SMN1; SMN2LMNADAO | |
| SCHEMBL18989645 | 0.75 | HDAC3 (0.46) | PARP1ALDH1A1RNASEH1LMNADAO | |
| SCHEMBL27771388 | 0.73 | PARP1 (0.46) | PARP1ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL5382897 | 0.73 | GSK3B (0.57) | PARP1DAOHCAR2 | |
| SCHEMBL8595641 | 0.72 | PARP1 (0.45) | PARP1ALDH1A1HPGDMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071913-A | 2-(1H-TETRAZOL-5-YL)-4'-(AS-TRIAZIN-YLMETHYL)BIPHENYLS; CARDIOVASCULAR DISEASES, ESPECIALLY HYPERTENSION AND CONGESTIVE HEART FAILURE | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2000-06-06 | — | — | US | disclosed |