Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.37 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.36 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18075712 | 0.81 | PDE2A (0.49) | QDPRSMURF2SMURF1MRGPRX4HIF1A | |
| SCHEMBL15028917 | 0.78 | SLC6A2 (0.38) | SMURF2SMURF1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6203042 | 0.75 | TP53 (0.52) | NPSR1 | |
| SCHEMBL21180421 | 0.75 | LMNA (0.56) | SMURF2SMURF1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL18097765 | 0.75 | SLC6A2 (0.36) | SMURF2SMURF1MRGPRX4SLC6A4SLC6A3 | |
| SCHEMBL11742998 | 0.74 | PDE2A (0.45) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL27544861 | 0.73 | ADAMTS5 (0.32) | SMURF2SMURF1 | |
| SCHEMBL21995126 | 0.71 | SLC6A2 (0.36) | SMURF2SMURF1MRGPRX4SLC6A4SLC6A3 | |
| SCHEMBL25309520 | 0.70 | QDPR (0.45) | QDPRMRGPRX4PDE4APDE4BPDE4C | |
| SCHEMBL1494122 | 0.70 | QDPR (0.49) | QDPRHIF1APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908865-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170275266-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275266-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM5A, KDM1A | QDPR 285/4885SMURF2 342/4885SMURF1 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.