SCHEMBL19404402

SCHEMBL19404402

OC1=CC=CCC1CNc1ccc2c(c1)CN(Cc1ccc(CN3COc4ccc(N5COc6ccccc6C5)cc4C3)cc1)CO2

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
HIF1A Q16665 1/20 0.35
ADRA2A P08913 1/20 0.30
ADRA2B P18089 1/20 0.30
ADRA2C P18825 1/20 0.30
TMEM97 Q5BJF2 1/20 0.30
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19404392 0.79 CYP2D6 (0.48) CYP3A4CYP2D6HIF1AADRA2AADRA2B
SCHEMBL19404972 0.74 HTR1A (0.30) ADRA2AADRA2CSIGMAR1
SCHEMBL20612947 0.69 CYP1A2 (0.44) CYP3A4CYP2D6HIF1AADRA2AADRA2B
SCHEMBL19404773 0.69 MAPT (0.47) HIF1A
SCHEMBL19404939 0.67 RAB9A (0.42) CYP3A4CYP2D6HIF1AADRA2AADRA2B
SCHEMBL19404393 0.67 SIGMAR1 (0.43) CYP3A4CYP2D6HIF1AADRA2AADRA2B
SCHEMBL19404570 0.67 VDR (0.41) ADRA2AADRA2BADRA2CTMEM97SIGMAR1
SCHEMBL21865868 0.67 CYP1A2 (0.55) CYP3A4CYP2D6HIF1ASIGMAR1
SCHEMBL19410641 0.63 CYP3A4 (0.35) CYP3A4CYP2D6HIF1A
SCHEMBL28677044 0.63 CYP1A2 (0.62) CYP3A4CYP2D6HIF1AADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017164260-A1 BENZOXAZINE COMPOUND, METHOD FOR PRODUCING SAME, AND BENZOXAZINE RESIN 学校法人近畿大学 2017-09-28 WO disclosed