Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 4/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | CPT1A | P50416 | 3/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296762 | 0.85 | HSD11B1 (0.51) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL38659451 | 0.85 | HSD11B1 (0.51) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL1329027 | 0.83 | HSD11B1 (0.55) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL12459662 | 0.83 | PPID (0.48) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL29504572 | 0.81 | PRMT5 (0.55) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL31430923 | 0.81 | PRMT5 (0.55) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL14818001 | 0.80 | SMN1; SMN2 (0.52) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL3361751 | 0.79 | PRMT5 (0.56) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL29785721 | 0.79 | PRMT5 (0.56) | HSD11B1ADAM17PRMT5WDR77NPC1 | |
| SCHEMBL22039535 | 0.76 | HSD11B1 (0.54) | HSD11B1ADAM17PRMT5WDR77NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436448-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | Merck Patent GmbH (DE) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017173048-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | WO | disclosed |
| US-20170283425-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283425-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | PPIG, PPIH, FKBP2 | HSD11B1 510/4885ADAM17 569/4885PRMT5 3434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.