Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.37 |
| ▸ | POLRMT | O00411 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.31 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.30 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.30 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.30 |
| ▸ | GAPDH | P04406 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19412424 | 0.89 | DOT1L (0.35) | DOT1LPOLRMTMAP4K4STING1TNIK | |
| SCHEMBL22972736 | 0.87 | ADRB1 (0.40) | DOT1LPOLRMTACVRL1STING1ADORA2A | |
| SCHEMBL30560912 | 0.87 | ADRB1 (0.40) | DOT1LPOLRMTACVRL1STING1ADORA2A | |
| SCHEMBL25008844 | 0.87 | ADRB1 (0.40) | DOT1LPOLRMTACVRL1STING1ADORA2A | |
| SCHEMBL10154373 | 0.87 | ADRB1 (0.40) | DOT1LPOLRMTACVRL1STING1ADORA2A | |
| SCHEMBL24606235 | 0.87 | ADRB1 (0.40) | DOT1LPOLRMTACVRL1STING1ADORA2A | |
| SCHEMBL17131353 | 0.81 | STING1 (0.34) | DOT1LACVRL1STING1ADORA2ADPP4 | |
| SCHEMBL26268832 | 0.81 | DOT1L (0.39) | DOT1LPOLRMTACVRL1MAP4K4STING1 | |
| SCHEMBL17106684 | 0.81 | DOT1L (0.35) | DOT1LPOLRMT | |
| SCHEMBL12000842 | 0.81 | DOT1L (0.31) | DOT1LPOLRMTACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002366-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-01-04 | — | — | US | disclosed |
| US-9777035-B2 | 4′-substituted nucleoside reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002366-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | DUT, HPRT1, RNGTT | DOT1L 799/4885POLRMT 7/4885ACVRL1 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.