Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19415208 | 0.77 | ALDH1A1 (0.44) | — | |
| SCHEMBL19415476 | 0.73 | ABL1 (0.31) | — | |
| SCHEMBL19415191 | 0.72 | RPS6KA3 (0.44) | — | |
| SCHEMBL19415160 | 0.70 | RAF1 (0.32) | — | |
| SCHEMBL22625601 | 0.63 | KDR (0.42) | — | |
| SCHEMBL25715615 | 0.62 | ALDH1A1 (0.32) | — | |
| SCHEMBL31003562 | 0.61 | LMNA (0.43) | LMNA | |
| SCHEMBL82306 | 0.61 | LMNA (0.43) | LMNA | |
| SCHEMBL14320151 | 0.60 | ALDH1A1 (0.33) | — | |
| SCHEMBL2322134 | 0.60 | AURKA (0.50) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271622-B1 | Heteroaryl derivatives as CFTR Modulators | VERTEX PHARMA (US) | 2017-10-04 | — | — | EP | disclosed |