Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562427 | 0.81 | RPS6KA3 (0.49) | RPS6KA3CHEK2POLQMKNK1MKNK2 | |
| SCHEMBL19415208 | 0.79 | ALDH1A1 (0.44) | RPS6KA3MKNK2PLK1KITBRAF | |
| SCHEMBL19415476 | 0.78 | ABL1 (0.31) | — | |
| SCHEMBL13561356 | 0.76 | RPS6KA3 (0.45) | RPS6KA3CHEK2POLQMKNK1MKNK2 | |
| SCHEMBL13026260 | 0.74 | HDAC2 (0.55) | MKNK1MKNK2PLK1HDAC2HDAC8 | |
| SCHEMBL19415146 | 0.72 | LMNA (0.31) | — | |
| SCHEMBL15730258 | 0.71 | MKNK1 (0.68) | RPS6KA3CHEK2MKNK1MKNK2PLK1 | |
| SCHEMBL4314837 | 0.67 | NPC1 (0.41) | PIK3CAHDAC8HDAC6 | |
| SCHEMBL22625601 | 0.67 | KDR (0.42) | RPS6KA3MAPK14BRAFRAF1 | |
| SCHEMBL19415160 | 0.67 | RAF1 (0.32) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271622-B1 | Heteroaryl derivatives as CFTR Modulators | VERTEX PHARMA (US) | 2017-10-04 | — | — | EP | disclosed |